Evidence for response inhibition as a control process distinct from the common executive function: A two-study factor analysis.

The dominant model of executive functions, which has held for over two decades, contends that various aspects of seemingly disparate forms of inhibitory control-for example, inhibiting a prepotent response, or inhibiting irrelevant thoughts and distractions-are in fact manifestations of a single latent executive function. Recent work, however, has cast doubt on this dominant model, as certain conditions can dissociate performance on tasks thought to index inhibitory control. Moreover, issues related to task reliability and latent estimation of inhibition processes have prompted questions about whether the structure of inhibitory control can even be reliably estimated at a latent level. We addressed these issues in two studies of healthy young adults (Study 1 N = 154, Study 2, N = 279), examining seven then 12 different tasks taken by prior research to assess inhibitory control. Contrary to the dominant model of executive functions, we found that, at a latent level, inhibitory control was best fit by a replicable two-factor solution, with response inhibition as a distinct executive function. Further, our data suggested that prior work on executive functions may not have observed a response inhibition factor due to task selections (i.e., including either one of two specific tasks was critical to identifying a separate response inhibition factor). Therefore, contrary to the current primary theoretical model of executive functions, these results suggest that response inhibition is, in fact, a distinct control process from the control process underpinning other forms of inhibition, which has important implications for designing interventions and assessing outcomes related to inhibitory control. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

The Hippocampus Supports Precise Memory for Public Events Regardless of Their Remoteness.

The necessity of the human hippocampus and surrounding medial temporal lobe structures to semantic memory remains contentious. Impaired semantic memory following hippocampal lesions could arise either due to partially intertwined episodic memories and/or retrograde/anterograde effects. In this study, we tested amnesic individuals with lesions in hippocampus and surrounding medial temporal lobe (n=7) and age-matched controls (n=14) on their ability to precisely recall the dates of famous public events that occurred either before (i.e., pre-lifetime) or after participants' birth date (lifetime). We show that deficits in dating precision are greatest for recent lifetime events, consistent with the notion that recent event memory may be particularly intertwined with episodic memory. At the same time, individuals with medial temporal lobe lesions showed more subtle impairments in their ability to date pre-birth and remote lifetime events precisely. Together, these findings suggest that the hippocampus and surrounding medial temporal lobe structures are important for representational precision of semantic memories regardless of their remoteness.

Assessing Trial-by-Trial Electrophysiological and Behavioral Markers of Attentional Control and Sensory Precision in Psychotic and Mood Disorders.

BACKGROUND AND HYPOTHESIS: The current study investigated the extent to which changes in attentional control contribute to performance on a visual perceptual discrimination task, on a trial-by-trial basis in a transdiagnostic clinical sample. STUDY DESIGN: Participants with schizophrenia (SZ; N = 58), bipolar disorder (N = 42), major depression disorder (N = 51), and psychiatrically healthy controls (N = 92) completed a visual perception task in which stimuli appeared briefly. The design allowed us to estimate the lapse rate and the precision of perceptual representations of the stimuli. Electroencephalograms (EEG) were recorded to examine pre-stimulus activity in the alpha band (8-13 Hz), overall and in relation to behavior performance on the task. STUDY RESULTS: We found that the attention lapse rate was elevated in the SZ group compared with all other groups. We also observed group differences in pre-stimulus alpha activity, with control participants showing the highest levels of pre-stimulus alpha when averaging across trials. However, trial-by-trial analyses showed within-participant fluctuations in pre-stimulus alpha activity significantly predicted the likelihood of making an error, in all groups. Interestingly, our analysis demonstrated that aperiodic contributions to the EEG signal (which affect power estimates across frequency bands) serve as a significant predictor of behavior as well. CONCLUSIONS: These results confirm the elevated attention lapse rate that has been observed in SZ, validate pre-stimulus EEG markers of attentional control and their use as a predictor of behavior on a trial-by-trial basis, and suggest that aperiodic contributions to the EEG signal are an important target for further research in this area, in addition to alpha-band activity.

The role of recollection and familiarity in visual working memory: A mixture of threshold and signal detection processes.

Whether working memory reflects a thresholded recollection process whereby only a limited number of items are maintained in memory, or a signal detection process in which each studied item is increased in familiarity strength, is a topic of considerable debate. A review of visual working memory studies that have examined receiver operating characteristics (ROCs) across a broad set of materials and test conditions indicates that both signal detection and threshold processes contribute to working memory. In addition, the role that these two processes play varies systematically across conditions, such that a threshold process plays a particularly critical role when binary old/new judgments are required, when changes are relatively discrete, and when the hippocampus does not contribute to performance. In contrast, a signal detection process plays a greater role when confidence judgments are required, when the materials or the changes are global in nature, and when the hippocampus contributes to performance. In addition, the ROC results indicate that in standard single-probe tests of working memory, items that are maintained in an active recollected state support both recall-to-accept and recall-to-reject responses; whereas in complex-probe tests, recollection preferentially supports recall-to-reject; and in item-recognition tests it preferentially supports recall-to-accept. Moreover, there is growing evidence that these threshold and strength-based processes are related to distinct states of conscious awareness whereby they support perceiving- and sensing-based responses, respectively. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

The role of recollection, familiarity, and the hippocampus in episodic and working memory.

The hippocampus plays an essential role in long-term episodic memory by supporting the recollection of contextual details, whereas surrounding regions such as the perirhinal cortex support familiarity-based recognition discriminations. Working memory - the ability to maintain information over very brief periods of time - is traditionally thought to rely heavily on frontoparietal attention networks, but recent work has shown that it can also rely on the hippocampus. However, the conditions in which the hippocampus becomes involved in working memory tasks are unclear and whether it contributes to recollection or familiarity-based responses in working memory is only beginning to be explored. In the current paper, we first review and contrast the existing amnesia literature examining recollection and familiarity in episodic and working memory. The results indicate that recollection and familiarity contribute to both episodic and working memory. However, in contrast to episodic memory, in working memory the hippocampus is particularly critical for familiarity-based rather than recollection-based discrimination. Moreover, the results indicate that the role of the hippocampus in working memory can be obscured due to 'criterion-induced process-masking' because it primarily supports intermediate-confidence recognition decisions. We then report results from a new working memory study examining the ability of amnesics to detect global and local changes in novel complex objects (i.e., fribbles), which indicates that the hippocampus plays an especially critical role in working memory when the task requires the detection of global rather than discrete changes. We conclude by considering the results in light of neurocomputational models and proposing a general framework for understanding the relationship between episodic and working memory.

When stress enhances memory encoding: The beneficial effects of changing context.

The effects of acute stress on memory encoding are complex, and we do not yet know all of the conditions that can determine whether stress at encoding improves or impairs memory. Recent work has found that changing contexts between encoding and stress can abolish the effects of post-encoding stress on memory, suggesting that context may play an important role in the effects of stress on memory. However, the role of context in the effects of stress on memory encoding is not yet known. We addressed this gap by examining the effects of context on the influence of acute stress on memory encoding. In a 2 × 2 experimental design, participants (N = 103) completed either a stressor (i.e., Socially Evaluated Cold Presser Test) or control task (i.e., warm water control) before completing a memory encoding task, which occurred in either in the same room as or a different room from the stressor or control task. Memory retrieval was tested for each participant within the context that they completed the encoding task. We found that, relative to nonstressed (i.e., control) participants, stressed participants who switched contexts prior to encoding showed better memory for both negative and neutral images. In contrast, when the stressor or control task occurred in the same room as memory encoding, stress had no beneficial effect on memory. These results highlight the importance of the ongoing context as a determinant of the effects of stress on memory encoding and present a challenge to current theoretical accounts of stress and memory.

Managing EEG studies: How to prepare and what to do once data collection has begun.

In this paper, we provide guidance for the organization and implementation of EEG studies. This work was inspired by our experience conducting a large-scale, multi-site study, but many elements could be applied to any EEG project. Section 1 focuses on study activities that take place before data collection begins. Topics covered include: establishing and training study teams, considerations for task design and piloting, setting up equipment and software, development of formal protocol documents, and planning communication strategy with all study team members. Section 2 focuses on what to do once data collection has already begun. Topics covered include: (1) how to effectively monitor and maintain EEG data quality, (2) how to ensure consistent implementation of experimental protocols, and (3) how to develop rigorous preprocessing procedures that are feasible for use in a large-scale study. Links to resources are also provided, including sample protocols, sample equipment and software tracking forms, sample code, and tutorial videos (to access resources, please visit: https://osf.io/wdrj3/).

Eye movements dissociate between perceiving, sensing, and unconscious change detection in scenes.

Detecting visual changes can be based on perceiving, whereby one can identify a specific detail that has changed, on sensing, whereby one knows that there is a change but is unable to identify what changed, or on unconscious change detection, whereby one is unaware of any change even though the change influences one's behavior. Prior work has indicated that the processes underlying these different types of change detection are functionally and neurally distinct, but the attentional mechanisms that are related to these different types of change detection remain largely unknown. In the current experiment, we examined eye movements during a change detection task in globally manipulated scenes, and participants indicated their change detection confidence on a scale that allowed us to isolate perceiving, sensing, and unconscious change detection. For perceiving-based change detection, but not sensing-based or unconscious change detection, participants were more likely to preferentially revisit highly changed scene regions across the first and second presentation of the scene (i.e., resampling). This increase in resampling started within 250 ms of the test scene onset, suggesting that the effect began within the first two fixations. In addition, changed scenes were related to more clustered (i.e., less dispersed) eye movements than unchanged scenes, particularly when the subjects were highly confident that no change had occurred - providing evidence for change detection outside of conscious awareness. The results indicate that perceiving, sensing, and unconscious change detection responses are related to partially distinct patterns of eye movements.

Individual differences in behavioral and electrophysiological signatures of familiarity- and recollection-based recognition memory.

Our everyday memories can vary in terms of accuracy and phenomenology. According to one theoretical account, these differences hinge on whether the memories contain information about both an item itself as well as associated details (remember) versus those that are devoid of these associated contextual details (familiar). This distinction has been supported by computational modeling of behavior, studies in patients, and neuroimaging work including differences both in electrophysiological and functional magnetic resonance imaging. At present, however, little evidence has emerged to suggest that neurophysiological measures track individual differences in estimates of recollection and familiarity. Here, we conducted electrophysiological recordings of brain activity during a recognition memory task designed to differentiate between behavioral indices of recollection and familiarity. Non-parametric cluster-based permutation analyses revealed associations between electrophysiological signatures of familiarity and recollection with their respective behavioral estimates. These results support the idea that recollection and familiarity are distinct phenomena and is the first, to our knowledge, to identify distinct electrophysiological signatures that track individual differences in these processes.

Episodic memory processes modulate how schema knowledge is used in spatial memory decisions.

Schema knowledge can dramatically affect how we encode and retrieve memories. Current models propose that schema information is combined with episodic memory at retrieval to influence memory decisions, but it is not known how the strength or type of episodic memory (i.e., unconscious memory versus familiarity versus recollection) influences the extent to which schema information is incorporated into memory decisions. To address this question, we had participants search for target objects in semantically expected (i.e., congruent) locations or in unusual (i.e., incongruent) locations within scenes. In a subsequent test, participants indicated where in each scene the target had been located previously, then provided confidence-based recognition memory judgments that indexed recollection, familiarity strength, and unconscious memory for the scenes. In both an initial online study (n = 133) and replication (n = 59), target location recall was more accurate for targets that had been located in schema-congruent rather than incongruent locations; importantly, this effect was strongest for new scenes, decreased with unconscious memory, decreased further with familiarity strength, and was eliminated entirely for recollected scenes. Moreover, when participants recollected an incongruent scene but did not correctly remember the target location, they were still biased away from congruent regions-suggesting that detrimental schema bias was suppressed in the presence of recollection even when precise target location information was not remembered. The results indicate that episodic memory modulates how schemas are used: Schema knowledge contributes to spatial memory judgments primarily when episodic memory fails to provide precise information, and recollection can override schema bias completely.

Stress and memory encoding: What are the roles of the stress-encoding delay and stress relevance?

The effects of acute stress on memory encoding are complex. Recent work has suggested that both the delay between stress and encoding and the relevance of the information learned to the stressor may modulate the effects of stress on memory encoding, but the relative contribution of each of these two factors is unclear. Therefore, in the present study, we manipulated (1) acute stress, (2) the delay between stress and encoding, and (3) the relevance of the information learned to the stressor. The results indicated that stress during encoding led to better memory for study materials that were related to the stressor relative to memory for study materials that were unrelated to the stressor. This effect was numerically reduced for materials that were encoded 40 min after stressor onset (23 min after the stressor had ended) compared with items encoded at the time of the stressor, but this difference was not significant. These results suggest that the relevance of the information learned to the stressor may play a particularly important role in the effects of stress on memory encoding, which has important implications for theories of stress and memory.

Markers of a plant-based diet relate to memory and executive function in older adults.

BACKGROUND: Although it is known that plant-based foods are important for physical health, little is known about the relationship between plant-based foods and cognitive health. Emerging evidence suggests that some macronutrients may influence cognition, but it is unclear which domains of cognition are involved; more importantly, it is unknown how a plant-based diet relates to cognition. OBJECTIVE: To examine associations between a plant-based dietary pattern and cognitive functioning. METHODS: Participants were 3,039 older adults who participated in the 2011-2014 waves of the National Health and Nutrition Examination Survey (NHANES). The present cross-sectional study used data on macronutrient intake from 24-hour dietary interviews, as well as performance on tests of long-term memory and executive function (i.e., delayed word recall, digit symbol substitution test, and animal fluency). Principal component analysis was used to extract a dietary pattern consistent with a plant-based diet. RESULTS: Greater adherence to a dietary pattern consistent with a plant-based diet was related to better performance on all cognitive tasks. Secondary analyses indicated that the associations between a plant-based dietary pattern and executive function accounted for the association between a plant-based dietary pattern and memory. Furthermore, this same plant-based dietary pattern was associated with reduced baseline inflammation in a separate dataset. CONCLUSIONS: Experimental manipulations are needed to determine the potential causal relations of these associations, but these results suggest that a plant-based diet relates to better cognition, especially through improved executive control. Future work should also attempt to extend these results by examining potential mechanisms underlying these associations, such as reduced inflammation.

Narratives bridge the divide between distant events in episodic memory.

Many studies suggest that information about past experience, or episodic memory, is divided into discrete units called "events." Yet we can often remember experiences that span multiple events. Events that occur in close succession might simply be linked because of their proximity to one another, but we can also build links between events that occur farther apart in time. Intuitively, some kind of organizing principle should enable temporally distant events to become bridged in memory. We tested the hypothesis that episodic memory exhibits a narrative-level organization, enabling temporally distant events to be better remembered if they form a coherent narrative. Furthermore, we tested whether post-encoding memory consolidation is necessary to integrate temporally distant events. In three experiments, participants learned and subsequently recalled events from fictional stories, in which pairs of temporally distant events involving side characters ("sideplots") either formed one coherent narrative or two unrelated narratives. Across participants, we varied whether recall was assessed immediately after learning, or after a delay: 24 hours, 12 hours between morning and evening ("wake"), or 12 hours between evening and morning ("sleep"). Participants recalled more information about coherent than unrelated narrative events, in most delay conditions, including immediate recall and wake conditions, suggesting that post-encoding consolidation was not necessary to integrate temporally distant events into a larger narrative. Furthermore, post hoc modeling across experiments suggested that narrative coherence facilitated recall over and above any effects of sentence-level semantic similarity. This reliable memory benefit for coherent narrative events supports theoretical accounts which propose that narratives provide a high-level architecture for episodic memory.

The hippocampus supports high-precision binding in visual working memory.

It is well established that the hippocampus is critical for long-term episodic memory, but a growing body of research suggests that it also plays a critical role in supporting memory over very brief delays as measured in tests of working memory (WM). However, the circumstances under which the hippocampus is necessary for WM and the specific processes that it supports remain controversial. We propose that the hippocampus supports WM by binding together high-precision properties of an event, and we test this claim by examining the precision of color-location bindings in a visual WM task in which participants report the precise color of studied items using a continuous color wheel. Amnestic patients with hippocampal damage were significantly impaired at retrieving these colors after a 1-s delay, and these impairments reflected a reduction in the precision of those memories rather than increases in total memory failures or binding errors. Moreover, a parallel fMRI study in healthy subjects revealed that neural activity in the head and body of the hippocampus was directly related to the precision of visual WM decisions. Together, these results indicate that the hippocampus is critical in complex high-precision binding that supports memory over brief delays.

Temporal proximity to the elicitation of curiosity is key for enhancing memory for incidental information.

Curiosity states benefit memory for target information, but also incidental information presented during curiosity states. However, it is not known whether incidental curiosity-enhanced memory depends on when incidental information during curiosity states is encountered. Here, participants incidentally encoded unrelated face images at different time points while they anticipated answers to trivia questions. Across two experiments, we found memory enhancements for unrelated faces presented during high-curiosity compared with low-curiosity states, but only when presented shortly after a trivia question. This suggests processes associated with the elicitation of curiosity-but not sustained anticipation or the satisfaction of curiosity-enhance memory for incidental information.

Why do we retrace our visual steps? Semantic and episodic memory in gaze reinstatement.

When we look at repeated scenes, we tend to visit similar regions each time-a phenomenon known as resampling Resampling has long been attributed to episodic memory, but the relationship between resampling and episodic memory has recently been found to be less consistent than assumed. A possibility that has yet to be fully considered is that factors unrelated to episodic memory may generate resampling: for example, other factors such as semantic memory and visual salience that are consistently present each time an image is viewed and are independent of specific prior viewing instances. We addressed this possibility by tracking participants' eyes during scene viewing to examine how semantic memory, indexed by the semantic informativeness of scene regions (i.e., meaning), is involved in resampling. We found that viewing more meaningful regions predicted resampling, as did episodic familiarity strength. Furthermore, we found that meaning interacted with familiarity strength to predict resampling. Specifically, the effect of meaning on resampling was attenuated in the presence of strong episodic memory, and vice versa. These results suggest that episodic and semantic memory are each involved in resampling behavior and are in competition rather than synergistically increasing resampling. More generally, this suggests that episodic and semantic memory may compete to guide attention.

The spatial distribution of attention predicts familiarity strength during encoding and retrieval.

The memories we form are determined by what we attend to, and conversely, what we attend to is influenced by our memory for past experiences. Although we know that shifts of attention via eye movements are related to memory during encoding and retrieval, the role of specific memory processes in this relationship is unclear. There is evidence that attention may be especially important for some forms of memory (i.e., conscious recollection), and less so for others (i.e., familiarity-based recognition and unconscious influences of memory), but results are conflicting with respect to both the memory processes and eye movement patterns involved. To address this, we used a confidence-based method of isolating eye movement indices of spatial attention that are related to different memory processes (i.e., recollection, familiarity strength, and unconscious memory) during encoding and retrieval of real-world scenes. We also developed a new method of measuring the dispersion of eye movements, which proved to be more sensitive to memory processing than previously used measures. Specifically, in 2 studies, we found that familiarity strength-that is, changes in subjective reports of memory confidence-increased with (a) more dispersed patterns of viewing during encoding, (b) less dispersed viewing during retrieval, and (c) greater overlap in regions viewed between encoding and retrieval (i.e., resampling). Recollection was also related to these eye movements in a similar manner, though the associations with recollection were less consistent across experiments. Furthermore, we found no evidence for effects related to unconscious influences of memory. These findings indicate that attentional processes during viewing may not preferentially relate to recollection, and that the spatial distribution of eye movements is directly related to familiarity-based memory during encoding and retrieval. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Precision, binding, and the hippocampus: Precisely what are we talking about?

Endel Tulving's proposal that episodic memory is distinct from other memory systems like semantic memory remains an extremely influential idea in cognitive neuroscience research. As originally suggested by Tulving, episodic memory involves three key components that differentiate it from all other memory systems: spatiotemporal binding, mental time travel, and autonoetic consciousness. Here, we focus on the idea of spatiotemporal binding in episodic memory and, in particular, how consideration of the precision of spatiotemporal context helps expand our understanding of episodic memory. Precision also helps shed light on another key issue in cognitive neuroscience, the role of the hippocampus outside of episodic memory in perception, attention, and working memory. By considering precision alongside item-context bindings, we attempt to shed new light on both the nature of how we represent context and what roles the hippocampus plays in episodic memory and beyond.

The effects of face inversion on perceiving- and sensing-based change detection.

Face perception is more difficult when faces are inverted compared to when they are upright. However, it is not known whether face inversion disrupts the ability to make perceiving-based discriminations (i.e., the ability to identify a specific feature change), or sensing-based discriminations (i.e., the ability to detect there was a change without the ability to identify what changed). In the current study, we used confidence-based receiver operating characteristics (ROCs) in a change detection test to examine the effect of face inversion on perceiving and sensing. In Experiment 1, face inversion led to a reduction in the probability of perceiving but did not impact sensing-based discriminations. In Experiment 2, we replicated these results, and verified that the findings based on ROC estimates paralleled participants' phenomenological experiences of perceiving and sensing. Furthermore, the perceiving-based face inversion effect was found to reflect a reduction in the ability to accurately report specific feature changes. These findings indicate that face inversion does not reduce the ability to sense there was a change in the absence of identification, but rather it reduces the ability to consciously identify specific characteristics of faces in service of perceiving-based discriminations. In addition, they suggest that sensing responds to global differences across the visual image, rather than to changes in holistic processing of the visual input. These results further our understanding of the face inversion effect and clarify the nature of the processes underlying visual perception. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Feel free to write this down: Writing about a stressful experience does not impair change detection task performance.

Acute stress impairs working memory (i.e., the ability to update and keep information in mind). Although that effect is well established, the boundaries around it are not. In particular, little is known about how recalling an unresolved stressor might influence working memory, or about how stress-or recalling a stressful event-influences the processes underlying working memory task performance (e.g., sustained/controlled attention vs. capacity). We addressed these issues in the present study (N = 171) by randomly assigning participants to write about an unresolved, extremely stressful experience (stressful writing condition; n = 85) or the events of the prior day (control condition; n = 86), and, subsequently, both measured change detection task performance and used computational cognitive modeling to estimate the processes underlying it-namely, attention, capacity, and bias. We found that, relative to the control task, writing about a stressful experience neither impaired performance on the change detection task nor altered any of the processes underlying performance on that task. These results show that the effects of writing about an unresolved, stressful episode do not parallel effects of acute stress on working memory, indicating that experiencing a stressor may have very different cognitive effects than recalling it at a later time. (PsycINFO Database Record (c) 2020 APA, all rights reserved).